Russ Read-Barrow

STAGE 4 Bowel cancer · lungs, chest nodes, liver

ON TREATMENT NOW 5-FU/folinic acid + cetuximab Maintenance from Cycle 7, about 12 Nov 2026. Irinotecan dropped after a partial response. Before that: FOLFIRI + cetuximab, C1 19 Aug – C6 29 Oct 2026.

BEFORE YOU GIVE ME ANYTHING UGT1A1 *28/*28 — poor metaboliser Slower irinotecan clearance: higher risk of neutropenia and diarrhoea, and a reduced dose should be considered. Also the cause of my Gilbert's syndrome, which raises bilirubin on its own. DPYD *1/*1 normal — standard 5-FU and capecitabine dosing is fine. ERCC1 / XPC variants — higher platinum toxicity risk. Oxaliplatin is excluded anyway.

DRUG ALLERGIES None known

ALSO Smouldering myeloma On haematology surveillance. Plus Gilbert's syndrome.

WHAT I TAKE

Cetuximab 1000 mg, every 14 days
5-FU 900 mg bolus + 5000 mg over 46 h, folinic acid 350 mg, every 14 days
Citalopram 30 mg mornings
Metformin MR 500 mg, building to twice daily
Melatonin 60 mg evenings · loratadine 10 mg
Chemo support: Akynzeo, dexamethasone, pegfilgrastim, domperidone, loperamide, doxycycline, Laxido, zopiclone as needed

Irinotecan 400 mg was part of this up to Cycle 6 and stops from Cycle 7.

IF I AM UNWELL I am on chemotherapy. If I have a fever or feel unwell, please treat it as possible neutropenic sepsis until proven otherwise: urgent bloods and antibiotics without waiting for results. My 24-hour chemotherapy helpline number is on the alert card in my wallet.

The whole picture: diagnosis, genetics, every treatment and how it went, latest bloods and scans.
fcancerwith.ai/my-one-view

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Patient-held and kept up to date by me, not by a hospital system. Check anything clinical against my source records at fcancerwith.ai/full-record. Not medical advice.