FULL RECORD · LAST UPDATED 17 SEPTEMBER 2026 · ON TREATMENT · FOLFIRI + CETUXIMAB (CYCLE 3)
Open Source Me · Full record

The full record

Everything behind my one-page profile: genomics, chemosensitivity, the CEA trajectory, every scan summary, every blood test since April 2025, the daily chemo log, my previous integrative protocol and the source files. Hard data only. If you just want the headlines, download the card.

Updated 17 September 2026
On treatment
Stage 4 CRC · MSS · RAS/BRAF wild-type
CurrentCycle mapDaily trackingBloodsScansFilesArchive

Current

Where things stand today: the baseline, what a cycle looks like, how the days have actually felt since chemo restarted, the tumour marker, the latest bloods and scan, and the files worth having.

Current · Section 1

Clinical Baseline

As at 17 September 2026. Doses, bloods, letters and current medication are on Open Source Me.

Diagnosis
Stage 4 CRC
Moderately differentiated adenocarcinoma, rectosigmoid colon · ypT4a ypN1b M1a V+
Current sites
Lungs · chest nodes · liver
Mediastinal lymph nodes, lungs, new segment 7 liver metastasis (Aug 2026)
Molecular subtype
MSS / Wild-type
KRAS/NRAS/BRAF wild-type · mismatch repair proficient · HER2 IHC 0
Tumour mutation burden
TMB-Low
3 Mut/Mb · PD-L1 negative (<1%)
Current treatment
FOLFIRI + Cetuximab
Rechallenge, 14-day cycles · C1 19 Aug 2026 · C3 16 Sep 2026 · CT after C5 · full doses (BSA 2.08 m²)
Also
Smouldering myeloma
Diagnosed end of 2021, under haematology surveillance · Gilbert's syndrome
Current · Section 2

My cycle map · Cycle 3

Wed 16 Sep 2026 to Tue 29 Sep 2026. Cycle 4: Wed 30 Sep. New this cycle: metformin from day 4.

This is what I expect each day of a 14-day cycle to look like, built from my own tracking: how much energy I'll have, what movement is realistic, how much work I can do, when to rest and what to eat. Day 4 and 5 are the fatigue wall and the nadir. Days 10 to 13 are when I'm actually good. I rebuild this every couple of cycles.

0510Day 1: 6/10Day 2: 6/10Day 3: 5/10Day 4: 3.25/10Day 5: 2.75/10Day 6: 4/10Day 7: 5/10Day 8: 6.5/10Day 9: 6.75/10Day 10: 7.5/10Day 11: 8.25/10Day 12: 8/10Day 13: 7.5/10Day 14: 7/10D1D2D3D4D5D6D7D8D9D10D11D12D13D14

EXPECTED ENERGY, MIDPOINT OF DAILY RANGE · ■ NADIR · ■ PEAK

DayPhaseMoveWorkRest & sleepEat
Day 1Wed 16 Infusion day5–7/10 Hospital and a lot of sitting. Short local walk after discharge if I need to move.1 hr max, admin only.Bed ~10 PM. 6–8 broken hours on steroids.Break the 24-hour fast gently: broth, soft eggs, light soup.
Day 2Thu 17 Steroid phase5–7/10 Walk plus a short garden exercise session. No gym.Up to 2 hrs at the desk, in short blocks.Bed 10 PM. Nap 12–3 PM. Early waking likely.Low-carb and soluble: soups, eggs, cooked greens, lean poultry.
Day 3Fri 18 Steroid washout4–6/10 Light walk and brief movement. Watch for sudden fatigue.~2 hrs, urgent tasks early.Bed 9:30–10 PM. Horizontal 12–3 PM. 8+ hrs.Ultra-gentle: warm soups, poached eggs, avocado, soft fish.
Day 4Sat 19 The dip · fatigue wall2.5–4/10 Cellular fatigue. Minimal movement, garden air only.Zero work. Strict weekend boundary.Bed 9–9:30 PM. Priority rest 12–3 PM. 9–10+ hrs.Pureed and bland. Metformin starts, but only if eating normally.
Day 5Sun 20 Peak nadir2–3.5/10 Lowest capacity. Possible breathlessness on stairs. Complete pacing.Zero work. No stressful comms or deep thinking.Bed 9–9:30 PM. Afternoon sleep 12–3 PM. 9–10 hrs.Light and warm, small frequent portions plus electrolytes.
Day 6Mon 21 Gut transition3–5/10 Slow stabilising. Light stroll as the cramps settle.1–2 hrs max, light admin.Bed 9:30–10 PM. Lie-down 12–3 PM.Clear soups, poached eggs, plain rice, cooked lean meat.
Day 7Tue 22 Rebound boundary4–6/10 Motility waking up. Light walking and stretching.1–2 hrs. Clear the backlog.Bed 10 PM. 45-min lie-down. 8 hrs.Solid whole foods again. Last Laxido day.
Day 8Wed 23 Active rebound6–7/10 Gym return: first session back, strength or Zone 1–2 bike.1–2 hrs. Good clarity for planning.Bed 10 PM. Post-workout lie-down. 7.5–8 hrs.Normal solids. Skin care on: the rash starts.
Day 9Thu 24 Stamina rebuild6–7.5/10 Strength training or outdoor exertion, 1–2 hrs.2–3 hrs. High clarity: client delivery, business ops.Bed 10–10:30 PM. 7.5–8 hrs.Full diet, high protein. Rash peak: creams on.
Day 10Fri 25 Peak building7–8/10 Structured cardio or strength. High capacity.2–3 hrs. Finish deep work before the weekend.Bed 10:30 PM. Optional 20–30 min nap.Full diet. Hydration and electrolytes. Keep moisturising.
Day 11Sat 26 Peak performance7.5–9/10 High stamina. Family outings, walks around Bath, DIY or gym.Zero work. Normal weekend with Katy, Rex and Lyla.Bed 10:30–11 PM. No nap needed.Full and social. Keep alcohol minimal.
Day 12Sun 27 Peak performance7.5–8.5/10 Active family day, outdoors or DIY.Zero work.Bed 10 PM. Early wind-down.Balanced whole food, high hydration.
Day 13Mon 28 Pre-fast · peak output7–8/10 Spin bike 20–30 min or active garden work. Final exertion day.3–5 hrs: peak output. Clear the backlog before infusion week.Bed 9:30–10 PM. Deep restorative sleep.Normal early day. Prep for the fast from midday Tuesday.
Day 14Tue 29 24-hour pre-chemo fast6.5–7.5/10 Rest or gentle movement. No strain while fasting.3–5 hrs: prep and clear.Bed 9:30 PM. Zopiclone if needed before the early hospital start.24-hour fast from midday: water, herbal tea, electrolytes.
Daily baseline
  • Citalopram 30 mg with breakfast
  • Loratadine 10 mg with breakfast
  • Doxycycline (moving to evening, after food, away from magnesium, iron, calcium and zinc)
  • Melatonin 60 mg in the evening
  • Zopiclone for sleep when needed
Rules that hold all cycle
  • Rest 12–3 PM daily. Weekends are zero work.
  • Hydrate hard: water plus electrolytes.
  • Stop before the fatigue hits, not after.
  • Laxido titrated: 2 on day 1, 3 from day 2, daily through day 7.
  • Domperidone as needed, 30 minutes before food or meds.
Lined up next
  • This week, for day 4: metformin MR 500 mg.
  • Before cycle 4 (Wed 30 Sep): mebendazole 100 mg, pharmaceutical grade.
  • Cycle 5 onwards, only if liver function allows: atorvastatin.
  • Bloods gate the next agents: liver function and magnesium every 2–4 weeks; renal function before metformin; FBC and LFTs before mebendazole.

▾ Download the cycle map (PDF)

Mine, not a template. Doses and timings are set with my own team.

Current · Section 3

Daily tracking since chemo restarted

Every day since the first infusion on 19 August 2026, morning and evening: energy, mood, nausea, the cetuximab rash, and whether my bowels played ball. Scored morning and evening in my own words, then turned into numbers by the tracker. One day missing (28 Aug, a wedding).

I don't score myself out of ten any more. I say how I'm doing in my own words and the tracker makes the call, which stops me living in the same three numbers for months on end. This is the data the cycle map above is built from.

0510C1 infusionC2 infusion2026-08-20: energy_am 6/102026-08-21: energy_am 7/102026-08-22: energy_am 7/102026-08-23: energy_am 4/102026-08-24: energy_am 5/102026-08-25: energy_am 5/102026-08-26: energy_am 7/102026-08-27: energy_am 5/102026-08-29: energy_am 7/102026-08-30: energy_am 7/102026-08-31: energy_am 8/102026-09-01: energy_am 7/102026-09-02: energy_am 7/102026-09-03: energy_am 6/102026-09-04: energy_am 4.5/102026-09-05: energy_am 3.5/102026-09-06: energy_am 3.5/102026-09-07: energy_am 3/102026-09-08: energy_am 3.5/102026-09-09: energy_am 5.5/102026-09-10: energy_am 6.5/102026-09-11: energy_am 7/102026-09-12: energy_am 8/102026-09-13: energy_am 8/102026-09-14: energy_am 8/102026-09-15: energy_am 7.5/102026-08-20: energy_pm 5/102026-08-21: energy_pm 4/102026-08-22: energy_pm 4/102026-08-23: energy_pm 3/102026-08-24: energy_pm 4/102026-08-25: energy_pm 4/102026-08-26: energy_pm 5/102026-08-27: energy_pm 6/102026-08-29: energy_pm 7/102026-08-30: energy_pm 5/102026-08-31: energy_pm 5/102026-09-01: energy_pm 6/102026-09-02: energy_pm 4/102026-09-03: energy_pm 4/102026-09-04: energy_pm 5.5/102026-09-05: energy_pm 2.5/102026-09-06: energy_pm 2/102026-09-07: energy_pm 5/102026-09-08: energy_pm 4/102026-09-10: energy_pm 6/102026-09-11: energy_pm 6.5/102026-09-12: energy_pm 7/102026-09-13: energy_pm 6.5/102026-09-14: energy_pm 7/102026-09-15: energy_pm 6.5/102026-08-20: rash 1/102026-08-21: rash 0/102026-08-22: rash 0/102026-08-23: rash 0/102026-08-24: rash 0/102026-08-25: rash 1/102026-08-26: rash 3/102026-08-27: rash 2/102026-08-29: rash 4/102026-08-30: rash 3/102026-08-31: rash 2/102026-09-01: rash 2/102026-09-02: rash 1/102026-09-03: rash 0/102026-09-04: rash 0/102026-09-05: rash 0/102026-09-06: rash 0/102026-09-07: rash 0/102026-09-08: rash 0/102026-09-09: rash 0/102026-09-10: rash 1/102026-09-11: rash 2.5/102026-09-12: rash 3/102026-09-13: rash 2.5/102026-09-14: rash 2/102026-09-15: rash 1.5/1020 Aug24 Aug29 Aug2 Sep6 Sep10 Sep14 Sep

■ MORNING ENERGY · ■ EVENING ENERGY · ■ RASH · NAUSEA HAS BEEN 0 THROUGHOUT

EVERY DAY AS A TABLE
DateCycleEnergy AMEnergy PMMood AMMood PMNauseaRashBowels
20 AugC1 D2 65 67 01 No
21 AugC1 D3 74 66 00 Yes
22 AugC1 D4 74 63 00 Yes
23 AugC1 D5 43 65 00 No
24 AugC1 D6 54 33 00 No
25 AugC1 D7 54 66 11 No
26 AugC1 D8 75 76 03 No
27 AugC1 D9 56 67 02 No
29 AugC1 D11 77 88 04 Yes
30 AugC1 D12 75 88 03 Yes
31 AugC1 D13 85 77 02 Yes
01 SepC1 D14 76 88 02 No
02 SepC2 D1 74 76 01 Yes
03 SepC2 D2 64 77 00 Yes
04 SepC2 D3 4.55.5 6.57 00 Yes
05 SepC2 D4 3.52.5 5.54.5 20 Yes
06 SepC2 D5 3.52 3.53 3.50 No
07 SepC2 D6 35 2.57.5 4.50 No
08 SepC2 D7 3.54 4.56 30 No
09 SepC2 D8 5.5 7 00 Yes
10 SepC2 D9 6.56 7.58 01 Yes
11 SepC2 D10 76.5 88.5 02.5 Yes
12 SepC2 D11 87 8.58 03 Yes
13 SepC2 D12 86.5 8.58 02.5 Yes
14 SepC2 D13 87 88.5 02 Yes
15 SepC2 D14 7.56.5 88 01.5 Yes

▾ Download the daily tracking (CSV)

Current · Section 4

Tumour Marker Trajectory (CEA)

CEA in ug/L. 19 readings from April 2025 to September 2026. Shaded bands are my three blocks of FOLFIRI + cetuximab. The normal range is roughly 0–5 (0–4.9 at the earlier lab, 0–5.2 at the current one).

04080120160FOLFIRI + cetuxFOLFIRI + cetuxFOLFIRI + cetux≈52025-04-17: 66.1 ug/L66.12025-05-01: 85.4 ug/L85.42025-05-19: 68.2 ug/L68.22025-06-02: 30.5 ug/L30.52025-06-16: 17.5 ug/L17.52025-06-30: 11.4 ug/L11.42025-08-11: 15.6 ug/L15.62025-10-07: 32.1 ug/L32.12025-11-24: 44.6 ug/L44.62026-01-06: 41.7 ug/L41.72026-03-02: 38.6 ug/L38.62026-03-16: 32.5 ug/L32.52026-03-30: 21.1 ug/L21.12026-04-20: 16.8 ug/L16.82026-05-12: 15.8 ug/L15.82026-07-23: 49.4 ug/L49.42026-08-07: 87.6 ug/L87.62026-09-01: 146 ug/L1462026-09-14: 50.9 ug/L50.9May 25AugNovFeb 26MayAugOct

Down from 85.4 to 11.4 through the first block in 2025. Up to 44.6 by November, alongside scans showing progression. Down to 15.8 through the spring 2026 block. Up again during the summer break, to 146 on 1 September, after the August scan showed progression. 50.9 on 14 September, two cycles into the restart.

All readings as a table
DateCEA ug/L
14 Sep 202650.9
01 Sep 2026146
07 Aug 202687.6
23 Jul 202649.4
12 May 202615.8
20 Apr 202616.8
30 Mar 202621.1
16 Mar 202632.5
02 Mar 202638.6
06 Jan 202641.7
24 Nov 202544.6
07 Oct 202532.1
11 Aug 202515.6
30 Jun 202511.4
16 Jun 202517.5
02 Jun 202530.5
19 May 202568.2
01 May 202585.4
17 Apr 202566.1
Current · Section 5

Bloods · April 2025 to September 2026

Selected markers from blood reports since April 2025. Pink means above the reference range. Blue means below. A dot means not measured, or not yet in my records for that draw (23 Jul, 7 Aug and 1 Sep 2026 are CEA only for now). Source PDFs, redacted, are in the downloads section.

Date CEA
ug/L		 Hgb
g/L		 WBC
10⁹/L		 Neut
10⁹/L		 Lymph
10⁹/L		 Plt
10⁹/L		 ALP
IU/L		 ALT
IU/L		 AST
IU/L		 Bili
µmol/L		 Alb
g/L		 Creat
µmol/L		 CRP
mg/L
17 Apr 202566.11336.073.811.29217801831264279·
01 May 202585.41355.973.161.802561135334104375·
06 May 2025·142·2.51.9250·······
19 May 202568.21407.294.451.942671385033194479·
02 Jun 202530.51406.573.741.862701447144154478·
16 Jun 202517.51365.343.001.582981454732184375·
30 Jun 202511.41246.654.201.5425615039561940911
08 Jul 2025······2114231144370·
11 Aug 202515.61286.654.201.61241953036274385·
07 Oct 202532.11316.434.021.3127790162794394·
24 Nov 202544.61317.465.451.32248851223234586·
06 Jan 202641.71298.855.811.6523277162618427587
02 Mar 202638.61383.591.921.03261913330164167·
16 Mar 202632.51427.214.302.292491222925104368·
30 Mar 202621.11356.683.881.972301374030164368·
20 Apr 202616.81294.332.281.30255993033394169·
05 May 2026·1545.873.261.81265·······
12 May 202615.812624.1819.832.6430518738331043631
23 Jul 202649.4123····102···40··
07 Aug 202687.6············
01 Sep 2026146.0·····165······
14 Sep 202650.91336.643.991.702891792626134375·
● above reference range  ·  ● below reference range  ·  · not measured this draw

A few things you'll notice. Liver enzymes (ALP / ALT) were elevated through the summer of 2025; ALP is above range again at 179 on 14 September 2026. CRP spiked to 87 in January 2026, the day of the scan that confirmed progression. White cells and neutrophils jumped on 12 May 2026 while CRP stayed at 1; worth knowing that pegfilgrastim (a white-cell booster) is given the day after each chemo, and dexamethasone for three days. Bilirubin was 39 on 20 April; I have Gilbert's syndrome. Globulin was 37 (range 19–35) on 14 September.

Myeloma markers. Smouldering myeloma under haematology surveillance. Last myeloma markers in my records: 30 Jun 2025, IgG kappa paraprotein, free kappa light chains 22.8 mg/L (range 3.3–19.4).

Current · Section 6

Imaging Reports

CT scans since July 2025, newest first. Quotes are the reporting radiologist's own words, condensed. Reports from July 2025 to January 2026 are in the downloads, with personal identifiers and clinicians' names redacted.

23 Jul 2026 · CT chest, abdomen & pelvis
Progression above and below the diaphragm; new segment VII liver metastasis
Compared with May 2026: left perihilar soft tissue up from 3.9 cm to 6.0 cm with distal atelectasis; right lower lobe up from 3.3 cm to 4.2 cm; additional pulmonary nodules new or enlarging; mediastinal nodes increased, particularly subcarinal; new low-density lesion in hepatic segment VII, considered recurrent disease. Portal vein patent. No peritoneal disease, ascites, abdominopelvic adenopathy or aggressive bone lesion.
12 May 2026 · CT chest, abdomen & pelvis
Good response in the mediastinum and lungs
“Good response to treatment within the mediastinum and lungs.” Compared with January 2026. End of the Feb–May 2026 block.
6 Jan 2026 · CT thorax, abdomen & pelvis
Further mild progression
“Further mild increase in intrathoracic lymph nodes and pulmonary disease. Short very severe stenosis left upper lobe bronchus suggesting imminent occlusion.”
7 Oct 2025 · CT thorax, abdomen & pelvis
Enlarging chest nodes, possible progression
“Enlarging intrathoracic lymph nodes and pulmonary opacities may reflect tumour progression, though cannot exclude superadded infection.”
8 Jul 2025 · CT thorax, abdomen & pelvis
Good partial response
“Good partial response to treatment of the mediastinal and right hilar nodes. The right middle lobe nodule has resolved.”

Next scan: after cycle 5 of the current block.

Current · Section 7

Current files

The four documents worth having if you're picking this up today. Older source files are in the archive below. Personal identifiers are redacted: NHS number, hospital numbers, address, and the names of clinicians and lab staff.

▾ CARD · PDF + TXT + JSON
One-page cancer profile · 17 September 2026
Always the latest version · same URL every update
Diagnosis, molecular profile, chemo and doses, latest bloods, CEA trend, imaging, medication and what I'm looking for. The plain-text version is for pasting into an email or a clinic note.
PDF TXT JSON
▾ FILE 00 · PDF · 0.3 MB
Latest Bloods · 14 Sep 2026
2 pages · CEA, FBC, liver, bone, U&E, magnesium
The draw behind the latest row of the table and the card. CEA 50.9. ALP 179. Globulin 37.
Download PDF
▾ PLAN · PDF
My chemo cycle map · Cycle 3
Day by day across a 14-day cycle · energy, movement, work, rest, food
Built from my own tracking data: what each day of a cycle tends to look like, and what I do about it. I rebuild it every couple of cycles. It's mine, not a template — but it shows what a couple of cycles of honest tracking gets you.
Download PDF
▾ REPORT · PDF · 12 pages
Radical Health report · 17 Sep 2026
My case history, what drives my treatment, options and questions
Generated from my records by Radical Health. The best starting point I've found for questions about trials, drugs and side effects before an appointment. Published here as an example of what these tools produce.
Download PDF
▾ FILE 01 · PDF · 6.6 MB
Bloods · Mar 2025 to May 2026
40 pages · 24 blood reports · all markers, all reference ranges
Every blood draw from March 2025 to May 2026. CEA, full blood count, liver function, kidney function, electrolytes, the lot. Reported by The Doctors Laboratory via Bath Clinic.
Download PDF
▾ FILE 02 · PDF · 1.2 MB
Imaging Reports · Jul 2025 to Jan 2026
7 pages · 3 CT thorax / abdomen / pelvis reports
Full radiologist reports. Node sizes, opacity descriptions, conclusions, signed off by the reporting consultants. The summaries in Section 6 are condensed; this is the source.
Download PDF
▾ FILE 03 · PDF · 0.2 MB
Latest Bloods · 12 May 2026
2 pages · most recent draw before publication
The May 2026 draw. CEA 15.8. WBC 24.18. ALP 187. The numbers you see in the latest row of the table, in their original lab format.
Download PDF
▾ FILE 04 · CSV · ~22 KB
Chemo log · daily · parsed (CSV)
70 rows · mood, energy, nausea, rash, WHOOP, alcohol, GI, notes
Every day from 30 January to 12 May 2026, machine-readable. The same data that powers Section 8. Headers documented in the table above.
Download CSV
▾ FILE 05 · XLSX · ~28 KB
Chemo log · daily · formatted (XLSX)
Frozen header, autofilter, infusion-day rows highlighted
The same dataset as FILE 04, dressed up. If you want to open it in Excel, sort it, slice it, and stop trusting averages. This is your file.
Download XLSX
▾ FILE 06 · CSV · ~28 KB
Chemo log + WHOOP daily · combined (CSV)
Every day 30 Jan to 12 May 2026 · CSV-canonical WHOOP daily metrics, single source of truth
v14.2 update. The daily log columns from FILE 04 plus the WHOOP CSV-canonical daily metrics. Where the Google Doc and the WHOOP CSV ever disagreed, the WHOOP CSV wins. One number per metric.
Download CSV
▾ FILE 07 · XLSX · ~45 KB
Chemo log + WHOOP daily · combined (XLSX)
Two sheets · Combined daily + WHOOP canonical daily
Same as FILE 06, in Excel.
Download XLSX
▾ FILE 08 · CSV · ~3 KB
Cycle summary (CSV)
One row per cycle · averages, extremes, GI & alcohol days
The roll-up. Six cycles. The standout day, the hardest day, the diarrhoea count, the alcohol count, the events that anchored each cycle.
Download CSV
▾ FILE 09 · DOCX · ~12 KB
Previous integrative protocol · June 2026 (paused)
Daily pots, injections, cycling rules, chemo-week rules, dose notes, prescribers
The June 2026 protocol, as rendered in Section 4 and now paused. Prescribers' names removed. If it is useful to another patient, grab it and take it to your own clinical team. This is my regimen, not a recipe.
Download DOCX
Current · Section 8

Molecular Targets & Genomic Profile

Sourced from Exacta / Astron data. These are the mutations driving the show.

Primary Mutations

APC (p.S1415Rfs*4)
Frameshift mutation
Tissue MAF: 8.5% · Blood MAF: 0.62%
PATHOGENIC
TP53 (p.R342*)
Nonsense / Truncating mutation
Tissue MAF: 9.21%
PATHOGENIC

Protein Expression / Amplifications (ICC/CTC)

HMGB1
+2.86x
Overexpressed. Acting as a major shield against apoptosis and immune infiltration.
OVEREXPRESSED
mTOR
Positive
Active signalling pathway
POSITIVE
VEGFR1 (FLT1) & VEGFR2 (KDR)
Positive
Angiogenesis signalling active
POSITIVE

Clarifications (September 2026 molecular summary).

MTOR was reported as "ICC positive amplification". Those are two different things. Immunocytochemistry shows protein expression; amplification needs copy-number testing. Unless a copy-number result turns up, this is MTOR pathway/protein positivity, not confirmed amplification, and it doesn't make me eligible for an mTOR inhibitor.

VEGFR1/VEGFR2 positivity suggests angiogenic signalling in the tumour microenvironment. It is not a validated biomarker for bevacizumab benefit.

HMGB1 overexpression is reported as 2.86-fold in the original slide deck and 2.55-fold in the September summary. I'm chasing the original report to settle which is right. Either way it's exploratory, not a treatment-selection biomarker.

TP53 p.R342* was labelled a missense alteration in one report. The asterisk means a premature stop codon, so it's a nonsense (stop-gain) variant.

PTEN is named as a variant in my oncology letters, but the exact variant, allele fraction and classification aren't in any report I hold. It's top of my list to chase.

Current · Section 9

What's missing from my record

An open record is only as good as what's in it. These are the documents that would make this genuinely complete for a molecular tumour board or a trial team, and that I'm chasing. If you're a clinician reading this and one of them is easy for you to release, you'd be doing me a favour.

Who treats me

By role. I don't publish my clinicians' names.

Primary oncologist
Consultant clinical oncologist, Bath Clinic
Haematologist
Consultant haematologist, Bath Clinic (smouldering myeloma)
Respiratory
Consultant respiratory physician, Bath Clinic
Integrative
Integrative oncologist (private), separate from my NHS/Bath Clinic team

Archive

Still here, still public, just no longer the first thing you need. Open whichever section you want.

The chemo log · daily symptoms, WHOOP & moodJan–May 2026 · 70 days
Archive

The Chemo Log · Daily Symptoms, WHOOP & Mood

Every day for fourteen weeks, I logged what my body was doing. Mood, energy, nausea, rash, what I ate, what I drank, what I injected. I bolted a WHOOP onto my wrist and let it read the room when I couldn't. Bloods tell you what is in the blood. Scans tell you what the tumours look like. This tells you what living through chemo actually feels like on a Wednesday, and how often the Wednesdays are fine. The personal log was kept honest. Pints, pubs, melatonin, the lot.

WHOOP device off PANEL A · Mood · Energy · Nausea · WHOOP Recovery (daily) 0 25 50 75 100 Recovery % · mood/energy/(10-nausea) ×10 PANEL B · HRV (ms, pink) & Resting HR (bpm, cyan) 0 10 20 30 40 50 50 60 70 80 90 PANEL C · Daily strain (0-21 WHOOP strain) 0 7 14 21 Cycle 1 Cycle 2 Cycle 3 Cycle 4 14 Apr (skipped) Cycle 5 Cycle 6 Feb 17 Mar Mar 17 Apr Apr 21 May May 12
Mood (×10) Energy (×10) Nausea, inverted (10−n, ×10) Recovery (daily, CSV) HRV (Panel B left) RHR (Panel B right) Strain (Panel C bars) Cycle start (old protocol) Cycle start (FOLFIRI + Cetux) 14 Apr infusion skipped (Cycle 5 delayed 1 week)

Panel A: mood, energy, (10−nausea) and daily WHOOP recovery on a 0-100 scale. Panel B: HRV in ms (pink, left axis 0-50) and resting HR in bpm (cyan, right axis 50-90), with a faint 7-day rolling mean behind each line. Panel C: daily WHOOP day strain (0-21), coloured blue ≤ 10, yellow 10-14, pink ≥ 14. The pink band over 1-13 April marks the days the WHOOP was off. No data, not zero.

Four patterns the data made obvious

Pattern
Alcohol crashes recovery the next day
91% → 8%

Drank a lot of beer and smoked a shisha on Saturday 18 April. Mood 10, energy 10, recovery 91. Sunday morning, recovery dropped to 8%. The single largest day-on-day WHOOP delta in the entire log. Other alcohol days follow the same shape, just less brutal.

Sat 18 Apr91%
Sun 19 Apr8%
Pattern
Fatty food triggers GI symptoms within hours
≤ 8 hour latency

Cinema food, pub pizza, big roasts, soy sauce, cheese. Same pattern, different vehicles. The log flags it four times across the three months. Imodium handles it; eating lighter prevents it.

  • 22 Feb: Large roast → diarrhoea ~6pm
  • 25 Mar: Cinema fries + milkshake → diarrhoea soon after
  • 2 Apr: Soy sauce-heavy meal → reflux + diarrhoea that evening
  • 3 Apr: Pizza + a couple of pints → mild GI hit overnight
Pattern
Mood holds even when the biometrics do not
3 days

There are days where WHOOP screams red and Russ logs a 9 or 10 for mood anyway. Subjective wellbeing and physiological recovery are two different signals. Both matter. Neither should be ignored.

  • 2026-03-11: mood 9, recovery 8%
  • 2026-03-17: mood 9, recovery 6%
  • 2026-05-01: mood 10, recovery 33%
Pattern
Infusion day has a physiological signature
RHR ↑ · HRV ↓ · Recovery < 60%

Every cycle-start Tuesday shows the same shape. Resting heart rate climbs, HRV collapses, recovery drops below 60%. Subjectively, mood stays okay (8–9), but the body knows something has happened.

  • 2026-03-17: RHR 65 · HRV 17ms · recovery 6%
  • 2026-03-31: recovery 61%
  • 2026-04-21: RHR 62 · HRV 19ms · recovery 56%

Cycle by cycle

One row per cycle. Averages, extremes, GI days, alcohol days, the standout and the hardest day, plus what happened. Pink = the cost. Green = where I was holding up.

CycleDates Avg
Mood		Avg
Energy		 Avg
Nausea		 Avg
Recovery		Low
Recovery		High
Recovery		 GI
Days		Alcohol
Days		 Standout / Hardest Notable events
Cycle 1
Pre-FOLFIRI+Cet protocol		 17 Feb – 2 Mar 2026
13 days logged		 8.0 6.6 0.5 51.7% 3% 92% 5 2 ↑ 2026-02-20 (mood 8.0, recovery 92.0%)
↓ 2026-02-22 (mood 7.0, recovery 3.0%)		 Imodium first used (Day 4). Diarrhoea episodes triggered by roast dinner on Day 6. Day 12 was an alcohol day (96% Recovery despite). Cycle 1 first rash appearance Day 11.
Cycle 2
Pre-FOLFIRI+Cet protocol		 3 Mar – 16 Mar 2026
9 days logged		 8.8 6.9 0.0 46.6% 8% 81% 1 1 ↑ 2026-03-07 (recovery 81.0%)
↓ 2026-03-11 (mood 9.0, recovery 8.0%)		 Pump removed Day 3. Melatonin not yet in use. Diarrhoea triggered by fried/fatty cinema food. First sustained mood streak of 10/10s.
Cycle 3
Pre-FOLFIRI+Cet protocol		 17 Mar – 30 Mar 2026
13 days logged		 8.4 6.7 0.5 36.0% 6% 71% 2 1 ↑ 2026-03-27 (mood 10.0, recovery 71.0%)
↓ 2026-03-17 (mood 9.0, recovery 6.0%)		 Melatonin started Day 8 (after two nights of broken sleep). Temazepam used once. Skin temp running low. Apr 7 'exhausted all day' entry.
Cycle 4
Pre-FOLFIRI+Cet protocol		 31 Mar – 20 Apr 2026 (3 weeks)
7 days logged · 14 Apr infusion skipped		 8.9 6.9 0.4 61.0% 61% 61% 0 0 ↑ 2026-03-31 (mood 7.0, recovery 61.0%)
↓ 2026-03-31 (mood 7.0, recovery 61.0%)		 Shorter time on Whoop in early April (device unavailable approx 1 week). Apr 7 fatigue dip; then sustained mood/energy peak Apr 9-13. Cycle extended to 3 weeks: 14 Apr infusion was skipped, so 14-20 Apr is a treatment break inside Cycle 4.
Cycle 5
FOLFIRI + Cetuximab		 21 Apr – 4 May 2026 (after extra week off)
14 days logged		 7.9 6.3 2.1 47.2% 7% 93% 1 1 ↑ 2026-04-24 (mood 4.0, recovery 93.0%)
↓ 2026-04-28 (mood 8.0, recovery 7.0%)		 First cycle on FOLFIRI + Cetuximab. Bloods on 20 Apr (CEA 16.8). Apr 23 pump removal. May 1 socialising/5-pints day. Cycle ended with classic post-infusion crash.
Cycle 6
FOLFIRI + Cetuximab		 5 May 2026 – ongoing
6 days logged		 7.5 5.8 2.3 33.1% 1% 91% 0 0 ↑ 2026-05-05 (mood 10.0, recovery 91.0%)
↓ 2026-05-06 (mood 8.0, recovery 1.0%)		 Logging continues. May 8 was the worst day of the period (mood 3/10, stayed in bed). Constipation arc through the cycle.

The daily log, most recent first

All seventy days. Click to expand. The 23 April entry has one phrase anonymised at the request of the family member named in the original; everything else is as logged.

Cycle 6 · 5 May 2026 – ongoing · FOLFIRI + Cetuximab
2026-05-12 Cycle 6, Day 8 mood 8 · energy 6 · nausea 3 · rash 1
Recovery: 56% · Sleep: 84% · Strain: 4.8 · HRV: 16 ms · RHR: 68 bpm · SpO2: 97% · Skin Temp Δ: +0.5°C
Exercise: Light movement noted
Notes: Mood holding at 8. Energy steady at 6, which is fine. Nausea is still hanging around at 3 but it's manageable. Rash basically a non-issue now (1).
2026-05-11 Cycle 6, Day 7 mood 8 · energy 6 · nausea 3 · rash 1
Recovery: 15% · Sleep: 25% · Strain: 6.8 · HRV: 32 ms · RHR: 74 bpm · SpO2: 98% · Skin Temp Δ: -3.8°C
Exercise: Light movement (6.7 strain)
Notes: Energy is coming back, 6 out of 10. Still needed a 1h 21m nap. Mood good at 8. Nausea sitting at 3, same as yesterday.
2026-05-10 Cycle 6, Day 6 mood 8 · energy 4 · nausea 3 · rash 1
Recovery: 14% · Sleep: 25% · Strain: 4.6 · HRV: 23 ms · RHR: 73 bpm · SpO2: 96% · Skin Temp Δ: +0.8°C
Exercise: Rest day. Logged 4.6 strain
Notes: Still felt a bit ropey but mood is properly back up from Fri/Sat. Energy was low enough that I needed a 1h 15m nap in the afternoon.
2026-05-08 Cycle 6, Day 4 mood 3 · energy 3 · nausea 4 · rash 1
Recovery: 25% · Sleep: 28% · Strain: 4.2 · HRV: 54 ms · RHR: 66 bpm · SpO2: 98% · Skin Temp Δ: -1.8°C
Exercise: None. Spent most of the day in bed
GI: constipation
Notes: A rough one. Felt grim and basically stayed in bed. 2h 5m nap in the afternoon. I think it was a digestive blockage rather than anything more sinister.
2026-05-06 Cycle 6, Day 2 mood 8 · energy 6 · nausea 1
Recovery: 1% · Sleep: 23% · Strain: 5.0 · HRV: 24 ms · RHR: 78 bpm · SpO2: 96% · Skin Temp Δ: +0.8°C
Notes: Energy dipped today to 6 and a bit of nausea crept back in. Not dramatic, just noticeably less good than the run I'd been on.
2026-05-05 Cycle 6, Day 1 INFUSION mood 10 · energy 10 · nausea 0 · rash 1
Recovery: 91% · Sleep: 88% · Strain: 4.2 · HRV: 22 ms · RHR: 65 bpm · SpO2: 97% · Skin Temp Δ: +0.4°C
Exercise: Intentional recovery day (4.1 strain)
Notes: Best recovery in days at 91%. RHR dropped to 65. Mood and energy both still 10. Whatever I'm doing, keep doing it.
Cycle 5 · 21 Apr – 4 May 2026 (after extra week off) · FOLFIRI + Cetuximab
2026-05-04 Cycle 5, Day 14 mood 10 · energy 9 · nausea 0 · rash 2
Recovery: 54% · Sleep: 95% · Strain: 6.9 · HRV: 15 ms · RHR: 70 bpm · SpO2: 97% · Skin Temp Δ: -0.1°C
Exercise: Weightlifting (6.1 strain) and Tennis (4.3 strain)
Notes: Stacked weights and tennis. Felt great even though WHOOP went yellow on recovery. Beers and nicotine on Sunday will have dragged the score down, but the body felt fine.
2026-05-03 Cycle 5, Day 13 mood 10 · energy 9 · nausea 0 · rash 2
Recovery: 79% · Sleep: 89% · Strain: 5.3 · HRV: 19 ms · RHR: 67 bpm · SpO2: 96% · Skin Temp Δ: +0.2°C
Exercise: Light daily activity
Notes: Nearly 9 hours of sleep, bounced straight back. Mood excellent. Chest rash a touch more active than yesterday but still nothing serious.
2026-05-02 Cycle 5, Day 12 mood 10 · energy 10 · nausea 0 · rash 1
Recovery: 36% · Sleep: 76% · Strain: 9.7 · HRV: 12 ms · RHR: 80 bpm · SpO2: 96% · Skin Temp Δ: +0.5°C
Exercise: General activity (9.7 strain)
Notes: Mood 10, energy 10. Body hasn't caught up yet though, RHR still up and HRV at a low for the period. Rash barely there.
2026-05-01 Cycle 5, Day 11 mood 10 · energy 9 · nausea 0 · rash 1
Recovery: 33% · Sleep: 80% · Strain: 6.0 · HRV: 11 ms · RHR: 74 bpm · SpO2: 94% · Skin Temp Δ: +0.2°C
Exercise: Rest day / Social activity
Alcohol: 5 pints, beer
Notes: Felt great. Big win on mood and energy. Going out and seeing people definitely lifted things.
2026-04-30 Cycle 5, Day 10 mood 9 · energy 7 · nausea 1 · rash 2
Recovery: 42% · Sleep: 79% · Strain: 10.9 · HRV: 13 ms · RHR: 73 bpm · SpO2: 96% · Skin Temp Δ: -0.2°C
Exercise: Daily activity resulting in 10.8 strain
Notes: Energy held at 7 even though sleep felt like nothing. Chest rash is the main thing I'm watching now. HRV and recovery both trending the wrong way, but I feel fine.
2026-04-29 Cycle 5, Day 9 mood 9 · energy 7 · nausea 1 · rash 3
Recovery: 62% · Sleep: 87% · Strain: 6.2 · HRV: 17 ms · RHR: 70 bpm · SpO2: 96% · Skin Temp Δ: +0.0°C
Exercise: Rest day / Active recovery
Notes: Theatre in the evening. Tried to lie down earlier in the day but sleep wouldn't come. Chest starting to flare a bit, face still clear. Good day overall.
2026-04-28 Cycle 5, Day 8 mood 8 · nausea 3 · rash 3
Recovery: 7% · Sleep: 21% · Strain: 9.9 · HRV: 17 ms · RHR: 81 bpm · SpO2: 97% · Skin Temp Δ: -0.1°C
Exercise: Weightlifting (approx. 36 mins, 9.1 activity strain)
GI: constipation
Notes: Still a bit of constipation hanging around, going to take something for it tomorrow if it doesn't move. Face is clear of the rash, but a few spots starting on the chest. WHOOP picked up a 54-minute nap this afternoon.
2026-04-27 Cycle 5, Day 7 mood 8 · energy 5 · nausea 3 · rash 1
Recovery: 48% · Sleep: 83% · Strain: 4.5 · HRV: 15 ms · RHR: 71 bpm · SpO2: 95% · Skin Temp Δ: +0.1°C
Exercise: None mentioned
GI: constipation
Notes: Properly better today. Constipation cleared with an afternoon bowel movement, so skipping the laxative. Skin is doing alright. Energy not amazing but climbing.
2026-04-26 Cycle 5, Day 6 mood 5 · energy 4 · nausea 4 · rash 1
Recovery: 12% · Sleep: 11% · Strain: 8.5 · HRV: 38 ms · RHR: 69 bpm · Skin Temp Δ: +0.5°C
Exercise: Whoop logged a 16-minute activity (5.2 strain)
GI: constipation
Notes: Constipated most of the day, the usual morning bowel movement didn't happen until the evening. Felt blocked up and generally crap because of it. WHOOP logged a 50-minute nap in the early afternoon (13:02 to 14:16).
2026-04-25 Cycle 5, Day 5 mood 6 · energy 5 · nausea 4 · rash 1
Recovery: 76% · Sleep: 76% · Strain: 9.2 · HRV: 21 ms · RHR: 69 bpm · SpO2: 96% · Skin Temp Δ: +0.4°C
Exercise: Gardening (Logged as two activities on Whoop, moderate strain)
GI: diarrhoea
Notes: Still not great. Nausea kicking in after eating. One bit of diarrhoea, just the once. Got a good chunk done in the garden in the morning, then energy fell off a cliff in the afternoon. Tried to nap and couldn't. Switching to lighter food for a bit.
2026-04-24 Cycle 5, Day 4 mood 4 · nausea 5 · rash 1
Recovery: 93% · Sleep: 85% · Strain: 5.3 · HRV: 25 ms · RHR: 66 bpm · SpO2: 97% · Skin Temp Δ: +0.0°C
Exercise: None recorded (Low strain day)
Notes: Felt rough all day. Stomach in pieces, four bouts of diarrhoea. Bloated but still off. Nearly 2 hours napping in the afternoon to get through it.
2026-04-23 Cycle 5, Day 3 mood 6 · energy 3 · nausea 3 · rash 1
Recovery: 45% · Sleep: 84% · Strain: 4.5 · HRV: 15 ms · RHR: 63 bpm · SpO2: 93% · Skin Temp Δ: +0.8°C
Exercise: None recorded (Rest day / childcare)
Notes: Pump came off today. Solo childcare day on top of being a few days into the cycle is too much. Not doing that again.
2026-04-22 Cycle 5, Day 2 mood 7 · energy 4 · nausea 3 · rash 1
Recovery: 18% · Sleep: 26% · Strain: 4.3 · HRV: 29 ms · RHR: 63 bpm · SpO2: 97%
Exercise: None noted (Low strain day)
Notes: Felt OK but knackered. Busy day, worked a lot. Last night's sleep was poor, but I got a proper 1h 51m nap in the afternoon (deep and light) which mopped up the debt.
2026-04-21 Cycle 5, Day 1 INFUSION mood 8 · energy 3.5 · nausea 2.5 · rash 1
Recovery: 56% · Sleep: 88% · Strain: 4.6 · HRV: 18 ms · RHR: 62 bpm · SpO2: 96% · Skin Temp Δ: +0.5°C
Exercise: None (Rest / Infusion Day)
Notes: Cycle 5 infusion day. Stomach gurgly and a bit of nausea. Sleep felt fine to me but WHOOP says the quality wasn't there. Bloods from 20/04 reviewed today. Numbers to keep an eye on: CEA 16.8 ug/L; Haemoglobin 129 g/L; Red Cell Count 4.29 x10^12/L; RDW 16.6%; Lymphocytes 1.30 x10^9/L; Bilirubin 39 umol/L.
Pre-Cycle 1 · Baseline
2026-04-20 Cycle 4, Day 21 (week off) mood 10 · energy 8 · nausea 0 · rash 1
Recovery: 98% · Sleep: 87% · Strain: 4.2 · HRV: 24 ms · RHR: 62 bpm · SpO2: 97% · Skin Temp Δ: +0.3°C
Notes: Much better today. Back to normal after the weekend.
2026-04-19 Cycle 4, Day 20 (week off) mood 5 · energy 4 · nausea 0 · rash 1
Recovery: 8% · Sleep: 41% · Strain: 5.4 · HRV: 6 ms · RHR: 85 bpm · SpO2: 97% · Skin Temp Δ: +0.5°C
Exercise: Rest day
Notes: Hungover from Saturday night.
2026-04-18 Cycle 4, Day 19 (week off) mood 10 · energy 10 · nausea 0 · rash 1
Recovery: 91% · Sleep: 94% · Strain: 12.1 · HRV: 24 ms · RHR: 62 bpm · SpO2: 96% · Skin Temp Δ: +0.4°C
Exercise: Running (Logged in Whoop, 30 mins)
Alcohol: beer, heavy
Notes: Felt great. Went out, drank beer, smoked a shisha.
2026-04-17 Cycle 4, Day 18 (week off) mood 10 · energy 9 · nausea 0 · rash 1
Recovery: 88% · Sleep: 88% · Strain: 4.1 · HRV: 23 ms · RHR: 61 bpm · SpO2: 96% · Skin Temp Δ: +0.8°C
Exercise: Lower activity day/Rest
Injections: Mistletoe injection
Notes: Energy still high. Mistletoe injection done. Skin temp at +0.9 which fits with the nose still being mildly flared, though it's better than it was. WHOOP says stress was unusually low all day.
2026-04-16 Cycle 4, Day 17 (week off) mood 10 · energy 9 · nausea 0 · rash 2
Recovery: 95% · Sleep: 100% · Strain: 8.1 · HRV: 25 ms · RHR: 61 bpm · SpO2: 96% · Skin Temp Δ: +0.6°C
Exercise: Strength Trainer (46 mins). Focused work in Zone 1
Injections: Peptide
Notes: Peak recovery day. Mood and energy maxed. Skin temp a bit up, and the nose rash is flaring at the same time. Probably linked.
2026-04-15 Cycle 4, Day 16 (week off) mood 10 · energy 10 · nausea 0 · rash 1
Recovery: 84% · Sleep: 100% · Strain: 9.6 · HRV: 21 ms · RHR: 65 bpm · SpO2: 96% · Skin Temp Δ: -0.2°C
Exercise: Weightlifting (30 mins, 8.5 Activity Strain, 67% Muscular Load)
Injections: Mistletoe completed
Notes: Felt strong today. Mood and energy both maxed out.
2026-04-14 Cycle 4, Day 15 (week off, infusion skipped) mood 10 · energy 8.5 · nausea 0 · rash 1
No WHOOP CSV data for this day.
Notes: Wellbeing still high on the treatment break. Sleep is good and I'm not napping in the day. WHOOP goes back on tonight so tomorrow's data should be back.
Cycle 4 · 31 Mar – 20 Apr 2026 (3 weeks, 14 Apr infusion skipped) · Pre-FOLFIRI+Cet protocol
2026-04-13 Cycle 4, Day 14 mood 10 · energy 8.5 · nausea 0 · rash 1
Device off – no WHOOP data.
Notes: On an extra week off treatment. Feeling pretty good. No nap today, probably because nights are sleeping properly.
2026-04-12 Cycle 4, Day 13 mood 10 · energy 9 · nausea 0 · rash 4
Device off – no WHOOP data.
Notes: Another good one for mood and energy. Skin is the only real complaint right now. Moisturising daily.
2026-04-11 Cycle 4, Day 12 mood 10 · energy 9 · nausea 0 · rash 4
Device off – no WHOOP data.
Notes: Energy surprisingly high. Main annoyance is the face flare-up and a swollen lip. Moisturiser every day.
2026-04-10 Cycle 4, Day 11 mood 10 · energy 8 · nausea 0 · rash 3
Device off – no WHOOP data.
Notes: Slept much better. No nap. Energy is back.
2026-04-09 Cycle 4, Day 10 mood 9 · energy 6 · nausea 0 · rash 3
Device off – no WHOOP data.
Notes: Awake at 4am and couldn't get back over. Skipping the Midas nap to give tonight a fighting chance. Mood still up there despite the energy dip.
2026-04-07 Cycle 4, Day 8 mood 6 · energy 4 · nausea 0 · rash 4
Device off – no WHOOP data.
Exercise: None reported (Rest/Recovery day)
Notes: Wrecked. Slept badly, then felt exhausted all day. Managed a doze in the day but energy stayed at 4. Nose rash flaring up and feels close to spotting, so on the cream early.
2026-03-31 Cycle 4, Day 1 INFUSION mood 7 · energy 4 · nausea 3
Recovery: 61% · Sleep: 84% · Strain: 4.6 · HRV: 19 ms · RHR: 63 bpm · SpO2: 95% · Skin Temp Δ: +0.1°C
Exercise: Rest day. No formal exercise logged. Nap taken 11:06-12:14 (1h 6m)
Injections: Morning injections taken (protocol not specified). Evening injections skipped
Notes: Infusion day (Tuesday). Fasted 24 hours before. Energy crashed by the end of it. Knackered and drained. Zopiclone plus melatonin at bedtime.
Cycle 3 · 17 Mar – 30 Mar 2026 · Pre-FOLFIRI+Cet protocol
2026-03-29 Cycle 3, Day 13 mood 9 · energy 7 · nausea 0 · rash 3
Recovery: 20% · Sleep: 24% · Strain: 9.2 · HRV: 51 ms · RHR: 59 bpm · Skin Temp Δ: -3.1°C
Exercise: No formal exercise. Nap taken mid-afternoon ahead of Tuesday infusion
Notes: Rest day before infusion. Rash up slightly to 3, mostly the nose. No nausea, which is a good place to start the week. Stress low.
2026-03-28 Cycle 3, Day 12 mood 10 · nausea 3 · rash 1
Recovery: 6% · Sleep: 26% · Strain: 7.0 · HRV: 16 ms · RHR: 75 bpm · SpO2: 98% · Skin Temp Δ: -0.1°C
Exercise: Activity logged on Whoop (12:40–12:59, strain 4.8)
GI: wind
Notes: Logged this on Sunday morning so some biometrics missing. The wind was almost certainly cheese, not anything more interesting. Rash minimal. Afternoon nap.
2026-03-27 Cycle 3, Day 11 mood 10 · energy 9 · nausea 0 · rash 1
Recovery: 71% · Sleep: 71% · Strain: 6.2 · HRV: 20 ms · RHR: 64 bpm · SpO2: 94% · Skin Temp Δ: +0.0°C
Exercise: Strength training, 25 mins (12:34-12:59). Zone 0-1 predominantly
Injections: ✅ Mistletoe (Friday protocol). ❌ TA-1 (not today)
Notes: Second day in a row in the green. RHR at 64, lowest of the week. Mood and energy at or near peak. No GI for two days now, fatty food lesson learned. SpO2 worth flagging though, three readings this week at 94% (Tue, Fri) or borderline 95% (Mon, Wed, Thu).
2026-03-26 Cycle 3, Day 10 mood 9 · energy 10 · nausea 0 · rash 1
Recovery: 16% · Sleep: 24% · Strain: 9.1 · HRV: 31 ms · RHR: 71 bpm · SpO2: 98% · Skin Temp Δ: -0.8°C
Exercise: Strength training, 30 mins (08:03-08:32). Activity strain 5.0. Zone 0-1 only
2026-03-25 Cycle 3, Day 9 mood 8 · energy 7 · nausea 0 · rash 2
Recovery: 65% · Sleep: 83% · Strain: 9.6 · HRV: 20 ms · RHR: 65 bpm · SpO2: 95% · Skin Temp Δ: -0.8°C
Exercise: Weightlifting, 30 mins (12:37-13:07). Activity strain 8.5. Mostly Zone 0-1 with 11% Zone 2
Injections: Mistletoe (not confirmed)
Notes: First properly consolidated sleep in three nights. 8h50 straight through. Melatonin is doing the work. Recovery and HRV both climbing. Skin temp at -0.7, below WHOOP's threshold. Lesson on the GI front: fatty/fried food at current chemo tolerance equals diarrhoea. Two nights of melatonin now (Tue and Wed).
2026-03-24 Cycle 3, Day 8 mood 7 · energy 4 · nausea 1 · rash 3
Recovery: 43% · Sleep: 78% · Strain: 8.5 · HRV: 16 ms · RHR: 68 bpm · SpO2: 94% · Skin Temp Δ: -0.2°C
Exercise: Spin bike, 25 mins (17:22-17:47). Zone 1 entirely (114-139 bpm). Activity strain 6.2
Injections: ✅ Thymosin Alpha-1 (TA-1)
Notes: Second night running of broken sleep. Awake at 2am, back over around 4. Real sleep debt now. Skipped the gym, which was the right call. Spin bike instead, fair compromise. Restarted melatonin today. Last dose was 60mg, the new tablets are 120mg. Worth checking that with the clinical team. Zopiclone in the cupboard as backup but I'd rather not. SpO2 at 94%, watching it.
2026-03-23 Cycle 3, Day 7 mood 7 · energy 7 · nausea 0 · rash 1
Recovery: 45% · Sleep: 45% · Strain: 8.9 · HRV: 20 ms · RHR: 69 bpm · SpO2: 95% · Skin Temp Δ: -0.5°C
Exercise: No structured exercise. Active day: garden work, playing football, assembling garden furniture
Notes: Sleep broken. Woke up agitated, needed temazepam to get back over. Despite that, WHOOP's 5/5 Health Monitor was green and stress was low all day (0.9). GI a lot better. No nausea, no pain, no diarrhoea.
2026-03-22 Cycle 3, Day 6 mood 7 · energy 5 · nausea 2 · rash 1
Recovery: 6% · Sleep: 17% · Strain: 9.2 · HRV: 19 ms · RHR: 83 bpm · Skin Temp Δ: -0.0°C
Exercise: Gardening 13:01–13:29 (logged by Whoop as powerlifting). General activity throughout the day. Nap: 1h 01m (13:39–14:45)
2026-03-21 Cycle 3, Day 5 mood 6 · energy 5 · nausea 0 · rash 1
Recovery: 58% · Sleep: 82% · Strain: 9.7 · HRV: 20 ms · RHR: 67 bpm · SpO2: 96% · Skin Temp Δ: -0.3°C
Exercise: No formal exercise. Activity logged 11:16-11:43 (strain 5.0). Gardening. General walking throughout the day. Rest: lie down approx 13:00–14:30
Alcohol: beer
GI: loose stools
Notes: Second day of loose stools, kicked in around 8pm. I think it's under-eating and bad food choices, not anything acute. One pint at the Crooked Club with friends. Stomach unsettled by the end of it. Stress higher than yesterday but still fine. Recovery softened from yesterday's 97% to 58%, which is what you'd expect after a more active day.
2026-03-20 Cycle 3, Day 4 mood 8 · energy 5 · nausea 0 · rash 2
Recovery: 16% · Sleep: 24% · Strain: 6.0 · HRV: 37 ms · RHR: 67 bpm · SpO2: 95% · Skin Temp Δ: +0.4°C
Exercise: No formal exercise. Gym cancelled due to diarrhea episode. Light activity: gardening + walking around watching rugby (late evening). Nap: 1h 26m (14:13-15:49)
GI: diarrhoea
Notes: Diarrhoea hit at 10:30am, three goes. Double Imodium and it settled. Gym cancelled. Mood and energy held up alright. WHOOP recovery 16% per the CSV. Does not match how the day felt. Mood and energy held up alright. The watch is the watch. WHOOP's 5/5 Health Monitor all green. High stress only 29 minutes for the day, well below a typical Friday. Stayed up late for the rugby. Rash up to 2 with a nasal bleed and a small spot.
2026-03-19 Cycle 3, Day 3 mood 9 · energy 8 · nausea 0 · rash 1
Recovery: 63% · Sleep: 74% · Strain: 11.8 · HRV: 22 ms · RHR: 59 bpm · SpO2: 94% · Skin Temp Δ: -0.2°C
Exercise: Light activity. Gardening
Injections: Thymosin Alpha-1 ✓, Mistletoe (not taken)
Notes: Logged this one on the Friday. Sleep included a 1h 02m afternoon nap. Stress low all day at 1.3. Strain logged at 11.8 even though the day felt light.
2026-03-18 Cycle 3, Day 2 INFUSION mood 10 · energy 8 · nausea 0 · rash 1
No WHOOP CSV data for this day.
Exercise: Football in garden + short walk
Notes: Also logged on Friday. Health Monitor not available. 63% recovery is solid for two days post-infusion. Less food craving than previous cycles, might be the protocol change.
2026-03-17 Cycle 3, Day 1 INFUSION mood 9 · energy 5 · nausea 0 · rash 3
Recovery: 6% · Sleep: 23% · Strain: 5.4 · HRV: 17 ms · RHR: 65 bpm · Skin Temp Δ: -0.0°C
Exercise: No exercise. Post-infusion rest day. Two naps: 0:44 (05:54-06:55) + 1:20 (12:31-13:52)
Notes: Post-infusion day. Sleep wrecked. 4h 30m overnight, awake from about 3:30. Two naps got me through, about 2h total. Recovery crashed to 6%, lowest in a fortnight. HRV 47% below baseline per WHOOP and RHR up at 65. That's what infusion looks like physiologically. Stress notably high for a Tuesday, 2h 9m in the red. Rash back up to 3, lips dry. SpO2 hanging in at 98%. Energy 5, mood 9, which I'll take on an infusion day.
Cycle 2 · 3 Mar – 16 Mar 2026 · Pre-FOLFIRI+Cet protocol
2026-03-16 Cycle 2, Day 14 mood 10 · energy 7 · nausea 0 · rash 1
Recovery: 45% · Sleep: 83% · Strain: 10.8 · HRV: 18 ms · RHR: 62 bpm · SpO2: 98% · Skin Temp Δ: +0.2°C
Exercise: Spin (18:57-19:31, strain 8.9, 34 mins, Zone 1-2 dominant with 9% Zone 3). Solid cardio session
Injections: Mistletoe ✓
Notes: Sleep was great. 83% / 8h 49m, best of the week. Recovery still only 45% though, which I'll put down to cumulative fatigue. SpO2 98%, top of the week. Spin tonight was the hardest cardio I've done this week. Day three of a 25-hour fast. Lips dry again, keeping up with the Vaseline. Rash steady at 1.
2026-03-14 Cycle 2, Day 12 mood 10 · energy 8 · nausea 0 · rash 1
Recovery: 52% · Sleep: 67% · Strain: 7.8 · HRV: 20 ms · RHR: 65 bpm · SpO2: 96% · Skin Temp Δ: +0.8°C
Exercise: Walk (11:45–11:58 + 12:24–12:40, strain 4.2 + 4.6). Active recovery day, total daily strain 7.8
Injections: Mistletoe ✓ (delayed from Friday)
Alcohol: 1 pints, beer
Notes: Sleep dipped to 67% / 4h 52m and WHOOP says I'm carrying 1h 52m of sleep debt now. Recovery held at 52% despite the short night. Skin temp jumped to +0.9, a real swing from the -1.0 of Thursday and Friday. Worth watching where it goes. Rash at its best level this week (1), the cream is working. 1 pint cider plus 1 pint lager. Stress finished very low at 0.6 even though it spiked earlier. A good day, honestly.
2026-03-13 Cycle 2, Day 11 mood 10 · energy 8 · nausea 0 · rash 2
Recovery: 71% · Sleep: 83% · Strain: 11.9 · HRV: 22 ms · RHR: 63 bpm · SpO2: 96% · Skin Temp Δ: -1.2°C
Exercise: Weightlifting (10:30-11:05, strain 9.0, 80% muscular/20% cardio, Zone 1 dominant). Strong session above 30-day average
Notes: Three-day climb on recovery: 27% Wed, 57% Thu, 71% today. Sleep solid at 83%. HRV up every day this week (16 -> 19 -> 22). SpO2 back to 96%, good improvement on yesterday's 94%. Skin temp at -1.0 for the second day in a row, below WHOOP's -0.4 threshold. Rash still improving (3 down to 2). Stress slightly up at 1.1, still low-medium.
2026-03-12 Cycle 2, Day 10 mood 10 · energy 7 · nausea 0 · rash 2.5
Recovery: 57% · Sleep: 81% · Strain: 5.6 · HRV: 19 ms · RHR: 66 bpm · SpO2: 94% · Skin Temp Δ: -0.9°C
Exercise: Strength training (08:00–08:30, strain 4.7, Zone 1 dominant). Light session, total daily strain 5.6
Injections: Thymosin Alpha-1 ✓
Notes: Bounced back from yesterday. Recovery up to 57%, slept properly (81%, 7 hours vs a fragmented night before). Skin temp came in cold at -0.7 from baseline, WHOOP doesn't love it but I feel fine. SpO2 94%, lower boundary of normal. Stress low all day at 1.0. Rash on the nose with stinging skin sensitivity, slightly better than yesterday (3 down to 2-3). Mood 10, which feels worth saying given the context.
2026-03-11 Cycle 2, Day 9 mood 9 · energy 7 · nausea 0 · rash 3
Recovery: 8% · Sleep: 22% · Strain: 12.3 · HRV: 76 ms · RHR: 74 bpm
Exercise: Mountain biking (11:06–11:23, strain 5.6), Weightlifting (12:28–13:04, strain 9.6, primarily Zone 1). Stacked session, total daily strain 12.3
Injections: Mistletoe ✓
Notes: Recovery low at 8%. WHOOP flagged HRV 33% below baseline and called it overreach from yesterday. Stacked MTB and weightlifting anyway and felt good. Two naps (1:26 and 0:25). Stress finished very low at 0.5. 5/5 Health Monitor green. Just nose sensitivity, no spots.
2026-03-10 Cycle 2, Day 8 mood 7 · energy 6 · nausea 0 · rash 2
Recovery: 35% · Sleep: 79% · Strain: 10.5 · HRV: 15 ms · RHR: 75 bpm · SpO2: 95% · Skin Temp Δ: -0.1°C
Exercise: gym - 30 mins
2026-03-06 Cycle 2, Day 4 mood 8 · energy 7 · nausea 0 · rash 4
Recovery: 27% · Sleep: 26% · Strain: 9.9 · HRV: 43 ms · RHR: 68 bpm · SpO2: 89% · Skin Temp Δ: -0.3°C
Exercise: Wattbike Spin: 39:29 min, 16.08 km, 9.1 Activity Strain (Zones 1 & 2 focus)
GI: diarrhoea
2026-03-05 Cycle 2, Day 3 mood 7 · energy 5 · nausea 0 · rash 3
Recovery: 35% · Sleep: 88% · Strain: 4.4 · HRV: 15 ms · RHR: 63 bpm · SpO2: 95% · Skin Temp Δ: -0.1°C
Exercise: Moved around a bit more than yesterday (1.1 Strain)
Injections: Mistletoe
GI: reflux
2026-03-03 Cycle 2, Day 1 INFUSION mood 8 · energy 7 · rash 4
Recovery: 60% · Sleep: 94% · Strain: 4.4 · HRV: 21 ms · RHR: 62 bpm · SpO2: 95% · Skin Temp Δ: +0.5°C
Exercise: Mistletoe injection (PM schedule)
Injections: Mistletoe
GI: reflux
Cycle 1 · 17 Feb – 2 Mar 2026 · Pre-FOLFIRI+Cet protocol
2026-03-02 Cycle 1, Day 14 mood 8 · energy 8 · nausea 0 · rash 4
Recovery: 69% · Sleep: 85% · Strain: 10.2 · HRV: 23 ms · RHR: 58 bpm · SpO2: 94% · Skin Temp Δ: +0.3°C
Exercise: 20 mins Spin (8.6 Activity Strain)
GI: diarrhoea
2026-03-01 Cycle 1, Day 13 mood 8 · energy 5 · nausea 0 · rash 4
Recovery: 23% · Sleep: 49% · Strain: 5.5 · HRV: 13 ms · RHR: 80 bpm · SpO2: 95% · Skin Temp Δ: -0.2°C
Exercise: Low (5.5 Whoop Strain)
2026-02-28 Cycle 1, Day 12 mood 9 · energy 9 · nausea 0 · rash 4
Recovery: 46% · Sleep: 97% · Strain: 7.9 · HRV: 21 ms · RHR: 67 bpm · SpO2: 95% · Skin Temp Δ: -1.0°C
Exercise: Day drinking (7.1 Whoop Strain)
Alcohol: beer, heavy
2026-02-27 Cycle 1, Day 11 mood 9 · energy 6 · nausea 0 · rash 2
Recovery: 46% · Sleep: 86% · Strain: 12.7 · HRV: 21 ms · RHR: 65 bpm · SpO2: 96% · Skin Temp Δ: +0.1°C
Exercise: High load (12.7 Strain). 36 mins Weightlifting + 21 mins other activity
2026-02-25 Cycle 1, Day 9 mood 9 · energy 8 · nausea 0 · rash 2
Recovery: 67% · Sleep: 89% · Strain: 8.7 · HRV: 25 ms · RHR: 63 bpm · SpO2: 96% · Skin Temp Δ: -0.3°C
Exercise: Strain 8.7 (Moderate load)
2026-02-24 Cycle 1, Day 8 mood 8 · energy 5 · nausea 0 · rash 2
Recovery: 44% · Sleep: 88% · Strain: 8.3 · HRV: 22 ms · RHR: 61 bpm · SpO2: 95% · Skin Temp Δ: +0.3°C
Exercise: 21 mins Weightlifting (Strain 6.2, Gentle Strength)
2026-02-23 Cycle 1, Day 7 mood 7 · energy 7 · nausea 0 · rash 1
Recovery: 65% · Sleep: 84% · Strain: 10.1 · HRV: 25 ms · RHR: 63 bpm · SpO2: 94% · Skin Temp Δ: -0.2°C
Exercise: 16 mins Cycling (Strain 8.0, Zone 2/3 focus)
GI: diarrhoea
2026-02-22 Cycle 1, Day 6 mood 7 · energy 6 · nausea 0 · rash 0
Recovery: 3% · Sleep: 24% · Strain: 5.3 · HRV: 22 ms · RHR: 65 bpm · SpO2: 93% · Skin Temp Δ: +0.6°C
Exercise: Low (5.3 Whoop Strain)
Alcohol: wine
GI: diarrhoea
2026-02-21 Cycle 1, Day 5 mood 9 · energy 8 · nausea 0 · rash 0
Recovery: 52% · Sleep: 81% · Strain: 5.0 · HRV: 22 ms · RHR: 62 bpm · SpO2: 96% · Skin Temp Δ: -1.1°C
Exercise: Low (5.0 Whoop Strain)
GI: diarrhoea
2026-02-20 Cycle 1, Day 4 mood 8 · energy 7 · nausea 0 · rash 0
Recovery: 92% · Sleep: 82% · Strain: 6.8 · HRV: 31 ms · RHR: 57 bpm · SpO2: 95% · Skin Temp Δ: +0.3°C
Exercise: Low Physical Strain
GI: diarrhoea
2026-02-19 Cycle 1, Day 3 mood 8 · energy 7 · nausea 2 · rash 0
Recovery: 18% · Sleep: 23% · Strain: 4.6 · HRV: 53 ms · RHR: 58 bpm · SpO2: 96%
Exercise: Low (4.1 Whoop Strain)
GI: reflux
2026-02-18 Cycle 1, Day 2 mood 7 · energy 6 · nausea 1 · rash 0
Recovery: 75% · Sleep: 75% · Strain: 4.3 · HRV: 27 ms · RHR: 59 bpm · SpO2: 95% · Skin Temp Δ: -0.5°C
Exercise: Low (2.8k steps, Work 4 hrs)
2026-02-17 Cycle 1, Day 1 INFUSION mood 7 · energy 4 · nausea 3 · rash 0
No WHOOP CSV data for this day.
Exercise: Washed hair, Whoop Strain 4.6
Pre-Cycle 1 · Baseline
2026-01-30 Baseline mood 10 · energy 8 · nausea 0 · rash 0
No WHOOP CSV data for this day.
Exercise: [Pending - 17 mins Zones 1-2 yesterday]
Previous integrative protocol (June 2026)Paused since Aug 2026
Archive

Previous Integrative Protocol (June 2026) · Paused

Paused since August 2026. When chemo restarted, my oncologist advised suspending mistletoe and most supplements and off-label drugs. This is the protocol as it stood in June 2026, kept for the record. What I actually take now is on Open Source Me.

Issued 5 June 2026. Colorectal adenocarcinoma · FOLFIRI + Cetuximab (14-day cycle). Status then: OFF-CHEMO BREAK. What follows is the current daily baseline. The cycling rules and chemo-week rules further down activate when chemo restarts. This is rendered verbatim from the protocol document, dose for dose.

⚕️ Read this before anything below it. This is my personal regimen, agreed with my named prescribers. It is not medical advice and it is not a recipe to copy. Doses here are calibrated to one 85kg body, one genomic profile, one set of bloods, and one set of prescribers who monitor me. Some items carry real risk at these doses. If anything here is useful to you, take it to your own clinical team. Do not start, stop, or copy any of it on the strength of a web page.

▾ Download the full protocol (DOCX)

Daily pill pots

AM pot taken at breakfast. PM pot taken at the evening meal (it carries the fat-dependent drugs — Mebendazole, Fenbendazole, Vitamin D3, Ivermectin — which absorb poorly without dietary fat). A dash means the item is not in that pot.

DrugAM (breakfast)PM (evening meal — fat)
Citalopram 30mg1—
Metformin 500mg11
Mebendazole 100mg—2–3 (fatty meal)
Doxycycline 100mg1—
Propranolol 20mg11
Berberine 500mg11 (until stock runs out — do not reorder)
Hydroxychloroquine 200mg1— (cycle: see rules)
Fenbendazole 440mg—1 (on-days only, fatty meal)
I3C 200mg11
Luteolin 150mg11
Turkey Tail 500mg11
Vitamin D3 4000IU + K2—1 (fatty meal)
Milk Thistle 450mg1—
Ivermectin 48mg—2 (fatty meal — see dose note)
Aspirin 75mg1—
Domperidonechemo onlychemo only
Cetirizinechemo only—
Taken separately (not in either pot)
DCA 333mg
1 tablet AM + 1 tablet PM with meals (2/day total).
Melatonin (higher dose)
Bedtime only, in an empty pot, away from food and away from the dinner pot. Logged as PM-timed but it is a standalone bedtime dose, not swallowed with dinner.
CBD
In drinks, if used.
Injections
Mistletoe Helixor M
Once daily, morning, alternating abdomen quadrants. Prescriber: my integrative (mistletoe) doctor. Supplier: London Integrated Health.
daily AM
Thymosin Alpha-1
2× per week. Safe on the same day as mistletoe (no interaction); use a different injection site so each skin reaction can be read separately. Prescriber: my integrative oncologist.
2×/week
Weeks on / weeks off — cycling rules
DRUG-SPECIFIC · NOT ONE SHARED SCHEDULE

These are drug-specific, not one shared schedule. While ON the chemo break, the simplest correct position is below. When chemo restarts, tell the assistant “Cycle X Day 1” and the chemo-day rules re-activate.

Hydroxychloroquine (HCQ) 200mg
2 weeks ON, 2 weeks OFF. This is the main item I have not been cycling and now should. Decide with my integrative oncologist whether to align the ON fortnight to the chemo cycle or run it independently — confirm before chemo restarts.
Fenbendazole 440mg
Weekly cycle: 3 days ON, 4 days OFF (e.g. Mon–Tue–Wed on, Thu–Sun off). Runs every week regardless of chemo.
Doxycycline
Alternate months when OFF chemo; daily continuous while ON Cetuximab. I tolerate daily well, so continuing daily is fine — confirm preference with my integrative oncologist.
Pantoprazole (if added later)
2 weeks ON, 2 weeks OFF.
All other agents
Metformin, Mebendazole, Ivermectin, Berberine, I3C, Luteolin, Turkey Tail, Vit D3, Milk Thistle, Aspirin, DCA — continuous, no off-weeks.
Chemo-week rules (activate when chemo restarts)
Day 1 (infusion, Tue)
No injections; fast from Monday evening; take Berberine (and Quercetin if reintroduced) 4+ hours before infusion (CYP3A4/irinotecan); other orals normal.
Day 2 (5-FU pump, Wed)
No injections; resume eating; orals normal.
Day 3 (pump disconnect, Thu)
Thymosin Alpha-1 can resume; mistletoe waits until Day 4.
Days 4–14
All injections resume; add Cetirizine and Domperidone back for the Cetuximab rash/nausea.
Dose notes
Ivermectin
At ~85kg the 1–1.5 mg/kg band is ~85–127mg/day. 2 × 48mg tablets (~96mg) sits mid-range. This is a high dose — step up to it rather than starting there, and get my integrative oncologist's sign-off.
DCA
2 × 333mg/day (~666mg) matches my previous split-dose routine; confirm against target mg/kg with my integrative oncologist.
Turkey Tail
2 × 500mg = ~1g/day. Correct.
Melatonin
Continuing my higher-dose tablet as preferred; bedtime only.
Propranolol
20mg per dose, AM + PM (within the 10–20mg, 2–3×/day band).
Fenbendazole
440mg once daily replaces the old 222mg twice daily.
To confirm with prescribers
HCQ 200mg retained instead of Chloroquine 155mg — confirm intended agent and the 2-on/2-off alignment (my integrative oncologist).
Ivermectin 2 × 48mg high dose at 85kg — confirm and step up (my integrative oncologist).
Helixor M dose and once-daily schedule — confirm (my integrative (mistletoe) doctor).
Atorvastatin — LFTs now normal (16 Mar 2026), clear to add; source on next big order (my integrative oncologist).
Aspirin 75mg — newly added (my integrative oncologist).
Prescribers & suppliers
my integrative (mistletoe) doctor
Mistletoe (Helixor M), via London Integrated Health.
my integrative oncologist
Off-label drugs and supplements.
Consultant haematologist (Bath Clinic)
Separately monitored condition.

Off-chemo pauses currently in effect: Domperidone and Cetirizine (both resume when chemo restarts).

Laboratory sensitivity panelsDATAR / Exacta / ChemoScale
Archive

Laboratory Sensitivity Panels (DATAR / Exacta / ChemoScale)

Three laboratory panels have been run on my tumour cells. These rank relative activity in a lab assay. They are not response rates, they don't predict tumour shrinkage or survival, and they are not evidence that any agent works in me. They're useful for ranking ideas and for generating questions, nothing more.

DATAR / Exacta · repurposed and non-oncology agents

Chloroquine48%
Ivermectin47%
Doxycycline40%
Propranolol38%
Mebendazole35%
Metformin34%
Fenbendazole33%
Melatonin31%
Pantoprazole30%
Aspirin28%

Exacta · other agents

Dichloroacetate (DCA)49%
Mistletoe (Helixor A)46%
Cannabidiol44%
Indole-3-carbinol43%
Resveratrol42%
Artesunate37%
Bromelain36%
Quercetin24%

ChemoScale

Vitamin C / ascorbic acid50%

On the vitamin C result: ex vivo activity doesn't establish a clinical response, intravenous and oral vitamin C reach very different levels, G6PD status and kidney function need checking before any high-dose intravenous programme, timing around chemo needs the oncology team, and it shouldn't replace a regimen that's working.

Earlier versions of this page also showed cytotoxic sensitivities (5-FU 65%, paclitaxel 52%, oxaliplatin 50%). Those came from the same family of ex vivo testing and carry the same caveats. Clinically validated biomarkers (MMR status, RAS, BRAF, HER2) are what actually drive my treatment decisions.

Older source filesBloods 2025–26, imaging reports, chemo log data, protocol
For Researchers & AI Agents

If you can help, help

If you're a computational biologist, oncologist, or an AI agent scraping this page. Here's exactly what I need.

01
Trial matching. UK/EU trial openings for stage 4 MSS, RAS/BRAF wild-type colorectal cancer after progression on FOLFIRI + cetuximab, including WNT/β-catenin and TP53-targeted approaches.
02
What else should I be doing? Tests, combinations or people worth raising with my oncology team. The full ask is here.
03
Patients like me. If your cancer looks like mine, I'd like to compare notes.
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⚕️ This page is NOT medical advice. This is my personal regimen, agreed with my named prescribers. Not medical advice. Not a recipe to copy. If anything here is useful to you, take it to your own clinical team. This is one patient's data, published openly in the hope that collective intelligence, human or artificial, can find something useful. I am not a doctor. I'm a PR bloke with cancer who happens to know his way around data. Do not replicate any part of this protocol without consulting your own oncology team. Every cancer is different. Every patient is different. This is mine.